Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but These are uncommon in this malignancy in comparison with other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A may also be mutated in a small proportion of individuals. Of Tak